https://en.bioecon.ru/clusters/downstream-purification/Recent content in Downstream-Purification on BioeconHugoen-USSun, 26 Jul 2026 12:35:40 +0700https://en.bioecon.ru/technology/crystallization-equipment-pharma-api/Sat, 25 Jul 2026 20:55:00 +0000https://en.bioecon.ru/technology/crystallization-equipment-pharma-api/The stirred, draft-tube-baffled, melt and continuous crystallizers — plus the inline FBRM/PVM probes that close the loop on them — that turn a purified API molecule into a defined polymorph with a target particle-size distribution, the unit operation on which bioavailability, purity and downstream filterability all depend.https://en.bioecon.ru/technology/disc-stack-centrifuges/Sat, 25 Jul 2026 14:20:58 +0000https://en.bioecon.ru/technology/disc-stack-centrifuges/High-speed centrifugal separators that stack conical discs to multiply settling area, clarifying fermentation broth and cell culture at 5,000–15,000 ×g with continuous automatic solids discharge — the primary harvest and clarification machine of bioprocessing, now extending into gamma-irradiated single-use bowls for small-batch and perfusion work.https://en.bioecon.ru/technology/downstream-purification-bioseparation/Fri, 19 Jun 2026 00:00:00 +0000https://en.bioecon.ru/technology/downstream-purification-bioseparation/Downstream purification converts crude bioreactor harvests into clinical-grade drug substance — chromatography (Protein A, IEX, HIC), tangential-flow filtration, and viral clearance together account for >50% of biomanufacturing CAPEX. The global DSP market exceeds $5B and grows at >8% CAGR driven by mAb and cell-gene therapy demand.https://en.bioecon.ru/technology/green-extraction-sc-co2-des-ultrasound/Mon, 01 Jan 0001 00:00:00 +0000https://en.bioecon.ru/technology/green-extraction-sc-co2-des-ultrasound/Advanced green extraction technologies including supercritical CO2, deep eutectic solvents, and ultrasound intensification for zero-residue bioactive recovery.