Companies
KU Leuven
Piet Herdewijn's group published structural work on a Thermococcus kodakarensis DNA polymerase (KOD-H4) engineered for HNA (hexose nucleic acid) reverse transcription, providing the first structural insight into how a DNA polymerase processes a xeno-nucleic acid backbone.
- Country
- Belgium
xna-chemistry
eu
Coverage
| CN | EU | US | |
|---|---|---|---|
| genome-engineering | ✓ | ✓ | ✓ |
Regulatorsfdaepamoa-china
Verifiable facts
| Fact | Value | Source |
|---|---|---|
| Affiliation | Department of Medicinal Chemistry, Rega Institute, KU Leuven, Belgium | pmc.ncbi.nlm.nih.gov · kuleuven.be |
| Research focus | Medicinal chemistry, drug discovery (virology, bacteriology, immunology, neurosciences), synthetic biology, nucleic acid chemistry, artificial genetic systems, and directed evolution of polymerases | research.kuleuven.be · ullapharmsci.org · michaeljfox.org |
| Grant | ERC grant for XNA development; Deutsche Forschungsgemeinschaft grant (MA2288/22-1); Medical Research Council grant (MC_U105178804) | doi.org · gbiomed.kuleuven.be · journals.plos.org · pmc.ncbi.nlm.nih.gov |
| Headcount | Approximately 20 PhD students and 15 Postdocs (as of 2019) | ullapharmsci.org |
| Principal staff | Piet Herdewijn, Mikhail Abramov, Frédérick Coosemans | doi.org · journals.plos.org · pmc.ncbi.nlm.nih.gov |
Independent sources: doi.org · journals.plos.org · michaeljfox.org · pmc.ncbi.nlm.nih.gov · ullapharmsci.org
Technologies
| Name | Cluster | Risk | |
|---|---|---|---|
| Xenobiology & expanded genetic alphabet (XNA) | genome-engineering | High | → |
Compiled by BIOECON from primary sources.
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