Peking University

researchers Chen Peng (College of Chemistry and Molecular Engineering) and Yi Chengqi (School of Life Sciences) published a June 2025 codon-expansion strategy using post-transcriptionally modified RNA codons — distinct from all 64 standard codons — to incorporate ncAAs into mammalian systems without disturbing the natu…

Country: China

codon-expansion cn

Coverage

	CN	EU	US
genome-engineering	✓	✓	✓

Regulatorsfdaepamoa-china

Verifiable facts

Fact	Value	Source
Affiliation	Peking University	newsen.pku.edu.cn · bio.pku.edu.cn · chem.pku.edu.cn
Research focus	RNA codon expansion, genetic code expansion, non-canonical amino acid incorporation, epitranscriptomics, and genome editing	newsen.pku.edu.cn · bio.pku.edu.cn
Facility	Synthetic and Functional Biomolecules Center (SFBC), Peking-Tsinghua Joint Center for Life Science, and Biomedical Pioneering Innovation Center (BIOPIC)	bio.pku.edu.cn · chem.pku.edu.cn · rcsb.org
Grant	National Basic Research Foundation of China (Grant 2014CB964900) and National Natural Science Foundation of China (Grants 31270838 and 21522201) medium confidence	rcsb.org
Publications	RNA codon expansion via programmable pseudouridine editing and decoding (Nature, 2025)	newsen.pku.edu.cn · pubmed.ncbi.nlm.nih.gov · chem.pku.edu.cn
Principal staff	Chen Peng and Yi Chengqi	bio.pku.edu.cn · chem.pku.edu.cn

Independent sources: bio.pku.edu.cn · chem.pku.edu.cn · newsen.pku.edu.cn · pubmed.ncbi.nlm.nih.gov · rcsb.org

Technologies

Name	Cluster	Risk
Xenobiology & expanded genetic alphabet (XNA)	genome-engineering	High	→

Compiled by BIOECON from primary sources.

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