# San Raffaele Telethon Institute

a leading European gene-therapy research institute exploring epigenetic editing to improve CAR-T cell function (reducing T-cell exhaustion), and in 2026 announced a manufacturing-scale-up collaboration with Cytiva to address gene-therapy production bottlenecks.

Source: https://en.bioecon.ru/companies/san-raffaele-telethon-institute/
Updated: 2026-07-03

- Country: Italy

## Verifiable facts

| Fact | Value | Source |
| --- | --- | --- |
| Affiliation | Joint venture between Fondazione Telethon and Ospedale San Raffaele | https://research.hsr.it/en/institutes/san-raffaele-telethon-institute-for-gene-therapy.html, https://sofinnovapartners.com/news/genespire-and-sr-tiget-announce-strategic-alliance-for-the-development-of-transformative-gene-therapies-for-genetic-diseases-and-disclose-collaboration-focus, https://www.fondazionetelethon.it/en/what-we-do/research/institutes/san-raffaele-telethon-institute-for-gene-therapy/ |
| Research focus | Gene and cell therapy, including gene and epigenetic editing, CAR-T cell engineering, and cancer immunotherapy | https://research.hsr.it/en/institutes/san-raffaele-telethon-institute-for-gene-therapy.html, https://www.fondazionetelethon.it/en/what-we-do/research/institutes/san-raffaele-telethon-institute-for-gene-therapy/ |
| Facility | Process Development Laboratory, GLP Test Facility, Vector Integration Core, Immune Core, Clinical Research Unit (including Clinical Hematology Research Unit and Pediatric Clinical Research Unit), SR-Tiget Clinical Lab | https://www.fondazionetelethon.it/en/what-we-do/research/institutes/san-raffaele-telethon-institute-for-gene-therapy/ |
| Grant | ERC Consolidator Grants 2024, Armenise-Harvard Foundation grant, From Bed to Bench grant, Horizon Europe-European Innovation Council grant (X-PAND) | https://research.hsr.it/en/institutes/san-raffaele-telethon-institute-for-gene-therapy.html, https://www.fondazionetelethon.it/en/what-we-do/research/institutes/san-raffaele-telethon-institute-for-gene-therapy/ |
| Principal staff | Luigi Naldini (Director), Alessandro Aiuti (Deputy Director and Head of Research Unit) | https://www.fondazionetelethon.it/en/what-we-do/research/institutes/san-raffaele-telethon-institute-for-gene-therapy/ |
| Headcount | Approximately 300 employees total (176 recorded in one source) | https://www.fondazionetelethon.it/en/what-we-do/research/institutes/san-raffaele-telethon-institute-for-gene-therapy/ |

Independent sources: fondazionetelethon.it, research.hsr.it, sofinnovapartners.com

## Technologies

- [Epigenome editing](https://en.bioecon.ru/technology/epigenome-editing/)