Companies
University of Barcelona / IBMB-CSIC
designed "celiacase," a recombinant enzyme active at gastric pH that degrades gluten immunogenic peptides — including the 33-mer fragment from wheat alpha-gliadin — synergistically with pepsin before they reach the duodenum, reducing intestinal atrophy, inflammation, antibody response and dysbiosis in mouse models;…
- Country
- Spain
Coverage
| CN | EU | US | |
|---|---|---|---|
| food-alt-protein | ✓ | ✓ | ✓ |
Regulatorsemafda
Verifiable facts
| Fact | Value | Source |
|---|---|---|
| Affiliation | Molecular Biology Institute of Barcelona (IBMB-CSIC), Institute for Research in Nutrition and Food Safety (INSA-UB), and Faculty of Pharmacy and Food Sciences at the University of Barcelona (UB) | ibmb.csic.es · rdcsic.dicat.csic.es · pcb.ub.edu |
| Research focus | Design and testing of recombinant enzymes (celiacase) for the degradation of gluten immunogenic peptides in coeliac disease management | ibmb.csic.es · link.springer.com · esrf.fr · pcb.ub.edu |
| Facility | Proteolysis Lab (IBMB-CSIC) | ibmb.csic.es |
| Facility | ESRF (European Synchrotron Radiation Facility) beamline ID23-1A | esrf.fr |
| Grant | Agencia Estatal de Investigación, Agència de Gestió d'Ajuts Universitaris i de Recerca (AGAUR), Generalitat de Catalunya, Ministry of Science and Innovation, and Catalan Coeliac Association | doi.org · pubmed.ncbi.nlm.nih.gov · rdcsic.dicat.csic.es |
| Principal staff | F. Xavier Gomis-Rüth (IBMB-CSIC), Francisco J. Pérez-Cano (INSA-UB), Marina Girbal-González (INSA-UB), Arturo Rodríguez-Banqueri (IBMB-CSIC) | ibmb.csic.es · pcb.ub.edu |
Independent sources: doi.org · esrf.fr · ibmb.csic.es · link.springer.com · pcb.ub.edu · pubmed.ncbi.nlm.nih.gov · rdcsic.dicat.csic.es
Technologies
| Name | Cluster | Risk | |
|---|---|---|---|
| Enzymatic therapy for celiac | food-alt-protein | Medium | → |
Compiled by BIOECON from primary sources.
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