# University of Zurich

Swiss and neighbouring institutes pioneer AAV-based delivery of prime editors for in-vivo correction of inherited metabolic liver defects.

Source: https://en.bioecon.ru/companies/university-of-zurich/
Updated: 2026-06-26

- Country: Switzerland

## Verifiable facts

| Fact | Value | Source |
| --- | --- | --- |
| Affiliation | Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland | https://doi.org/10.1101/2024.01.22.575834 |
| Research focus | Development of CRISPR-based genome editing tools including base and prime editors for in vivo treatment of inherited metabolic diseases such as phenylketonuria, citrullinemia type I, and hypercholesterolemia | https://doi.org/10.1126/scitranslmed.abl9238, https://www.itinerare.uzh.ch/en/Research/Correcting-genetic-diseases-by-base--and-prime-editing-.html, https://www.labmanager.com/compact-gene-scissor-enables-effective-genome-editing-32871, https://www.news.uzh.ch/en/articles/media/2022/ERC-Consolidator-Grants.html |
| Facility | Schwank Lab, Institute of Pharmacology and Toxicology, University of Zurich | https://doi.org/10.1101/2024.01.22.575834 |
| Grant | SNSF grant no. 310030_185293, SERI funded ERC-CoG 'GeneRepair', UZH Research Priority Programs (ITINERARE, Human Reproduction Reloaded), Novartis Foundation for Medical-Biological Research no. FN20-0000000203, SNSF Spark fellowship no. 196287, University Zürich Candoc grant no. FK-22-033 | https://doi.org/10.1101/2024.01.22.575834 |
| Publications | Peer-reviewed articles in journals such as Science Translational Medicine, Nature Biomedical Engineering, and bioRxiv regarding in vivo prime editing for metabolic liver defects | https://doi.org/10.1038/s41551-025-01399-4, https://doi.org/10.1101/2024.01.22.575834, https://doi.org/10.1126/scitranslmed.abl9238, https://doi.org/10.1126/scitranslmed.aec7274 |
| Principal staff | Gerald Schwank (Professor and Group Leader), Tatjana Haenggi (Lab Manager) | https://doi.org/10.1101/2024.01.22.575834, https://schwanklab.org/people/, https://www.med.uzh.ch/de/fakultaet/fakultaetsmitglieder/schwankgerald.html |

Independent sources: doi.org, itinerare.uzh.ch, labmanager.com, med.uzh.ch, news.uzh.ch, schwanklab.org

## Technologies

- [Prime editing](https://en.bioecon.ru/technology/prime-editing/)