# Yale University (Isaacs Lab)

"Ochre" genomically recoded organism — Next-gen GRO succeeding C321.ΔA, single dedicated stop codon.

Source: https://en.bioecon.ru/companies/yale-isaacs-lab/
Updated: 2026-07-05

- Country: United States

## Verifiable facts

| Fact | Value | Source |
| --- | --- | --- |
| Affiliation | Yale University | https://medicine.yale.edu/profile/farren-isaacs/, https://news.yale.edu/2025/02/06/yale-scientists-recode-genome-programmable-synthetic-proteins |
| Research focus | Engineering genomically recoded organisms (GROs) for programmable synthetic proteins and biocontainment | https://news.yale.edu/2025/02/06/yale-scientists-recode-genome-programmable-synthetic-proteins, https://www.nature.com/articles/s41586-024-08501-x, https://www.yalescientific.org/2025/09/no-stopping-now/ |
| Facility | Isaacs Lab at Yale Systems Biology Institute (West Campus) | https://news.yale.edu/2025/02/06/yale-scientists-recode-genome-programmable-synthetic-proteins, https://pmc.ncbi.nlm.nih.gov/articles/PMC11903333/, https://westcampus.yale.edu/news |
| Grant | National Institutes of Health (NIH), National Institute of General Medical Sciences, Defense Advanced Research Projects Agency (DARPA), National Science Foundation (NSF), Department of Energy, and Blavatnik Fund for Innovation at Yale | https://exa.ai/library/legal/patent/0tkr1wnn3ctqnl8pk0qz7r, https://ventures.yale.edu/news/blavatnik-fund-innovation-yale-support-12-life-sciences-projects-2026-spanning-oncology, https://www.nature.com/articles/s41586-024-08501-x |
| Publications | 90-100 scholarly works | https://www.nature.com/articles/s41586-024-08501-x |
| Principal staff | Farren Isaacs (Principal Investigator) | https://medicine.yale.edu/profile/farren-isaacs/, https://news.yale.edu/2025/02/06/yale-scientists-recode-genome-programmable-synthetic-proteins |

Independent sources: exa.ai, medicine.yale.edu, nature.com, news.yale.edu, pmc.ncbi.nlm.nih.gov, ventures.yale.edu, westcampus.yale.edu, yalescientific.org

## Technologies

- [Xenobiology & expanded genetic alphabet (XNA)](https://en.bioecon.ru/technology/xenobiology-expanded-genetic-alphabet/)