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Industrial chemistry

What changes this industry: bio-solutions with evidence, technologies, suppliers and open money.

Platform chemicalsSpecialty & fine chemicalsEnzymes & biocatalysis

Overview of the industry

Hazardous solvents, catalysts, biocides and bleaching chemicals in industry, and bio-based or biotechnological alternatives.

Products and processes need national authorization and site-specific engineering. The articles are overviews, not design or regulatory advice. Check current regulations.

Articles#

IDAlternativeReplacesRating
I01Bio-based and safer solventsN-methyl-2-pyrrolidone (NMP), N,N-dimethylformamide (DMF), dimethylacetamide (DMAc), dichloromethane (DCM), chloroform, toluene/xylene in some usesReplace (many applications) / Partial (some polymer and battery uses)
I02Industrial biocatalysis (enzymes and whole cells)Copper-catalysed sulfuric-acid hydration of acrylonitrile; rhodium-catalysed high-pressure asymmetric hydrogenation; chemical deacylation of penicillin G with…Replace (for many specific processes)
I03Biodegradable, bio-based lubricants and hydraulic fluids (vegetable-oil and synthetic esters)Mineral-oil hydraulic fluids, chainsaw bar oils, gear and stern-tube oils, greases (and total-loss lubricants lost directly to the environment)Replace (most uses)
I04Oil-reservoir and pipeline souring (H2S) control by nitrate injection (biocompetitive exclusion by nitrate-reducing bacteria)Glutaraldehyde, THPS (tetrakis(hydroxymethyl)phosphonium sulfate), quaternary ammonium biocides, acrolein and other biocides injected into water-flooded reservoirs,…Replace / Partial (depending on reservoir)
I05Pulp bleaching with xylanase enzyme pre-bleaching and ECF/TCF processes (oxygen, peroxide, ozone)Elemental chlorine (Cl2) and hypochlorite bleaching of kraft/sulfite pulp; reduces chlorine dioxide demand in ECFReplace
I06Petrochemical surfactants in cleaning · fermentation biosurfactants (rhamnolipids, sophorolipids)LAS, AEO, APEO; solvent-based cleanersPartial / Replace (specific uses)
I07Laundry and dishwashing → detergent enzymes (Europe washes ~6 °C colder since 1997)Phosphates, extra surfactant, hot washingReplace / Partial

Suppliers — real products and services (from the vendor index)#

Collection-level join (2026-09-28): active vendors matched by topic tags (organic-acids 39, enzymes 58, synbio-platform 33 companies in the index — the biocatalysis and bio-based chemical chains); open each card for evidence, contacts and status.

CompanyRegion · CountryWhat the index showsCard
Cathay BiotechAsia · Chinabio-based chemicals (long-chain acids/esters)card
Qianjiang BiochemicalAsia · Chinabiochemistry products (listed)card
SyncoZymesAsia · Chinabiocatalysis platformcard
NOVALatAm · Argentinabiotechnology platformcard

Reviewed but SKIPPED (no proven bio-alternative)#

Substance / useHazardNote
Chrome plating (Cr VI)CarcinogenTrivalent chromium and other coatings are chemical, not bio
Industrial cooling-water biocidesAquatic toxicityBiofilm management and bio-dispersants are emerging; not covered

What it replaces 7

D2Biodegradable, bio-based lubricants and hydraulic fluids (vegetable-oil and synthetic esters) — instead of mineral-oil lubricants in forestry, agriculture, marine, rail and water-adjacent machinery
Replaces: Mineral-oil hydraulic fluids, chainsaw bar oils, gear and stern-tube oils, greases (and total-loss lubricants lost directly to the environment)
2CHEM
D2Detergent enzymes for low-temperature washing instead of phosphates, extra surfactant and hot washing
Replaces: Phosphate builders (STPP), part of the fossil-based surfactant load, and high wash temperatures (60–90 °C) needed to remove protein, starch and fat …
7CHEM
D2Industrial biocatalysis (enzymes and whole cells) — e.g. nitrile hydratase for acrylamide, engineered transaminase for sitagliptin, enzymatic antibiotic side-chain processes — instead of heavy-metal catalysts, high-pressure hydrogenation and multistep chemistry with toxic reagents
Replaces: Copper-catalysed sulfuric-acid hydration of acrylonitrile; rhodium-catalysed high-pressure asymmetric hydrogenation; chemical deacylation of …
6CHEM
D2Oil-reservoir and pipeline souring (H2S) control by nitrate injection (biocompetitive exclusion by nitrate-reducing bacteria) — instead of continuous biocide dosing
Replaces: Glutaraldehyde, THPS (tetrakis(hydroxymethyl)phosphonium sulfate), quaternary ammonium biocides, acrolein and other biocides injected into …
1SERV
D1Bio-based and safer solvents — Cyrene (dihydrolevoglucosenone from cellulose), 2-methyltetrahydrofuran (2-MeTHF from furfural/levulinic acid), ethyl lactate, bio-ethanol, γ-valerolactone, limonene — instead of NMP, DMF, DMAc, dichloromethane and other hazardous solvents
Replaces: N-methyl-2-pyrrolidone (NMP), N,N-dimethylformamide (DMF), dimethylacetamide (DMAc), dichloromethane (DCM), chloroform, toluene/xylene in some uses
1CHEM
D1Biosurfactants (rhamnolipids, sophorolipids) instead of petrochemical surfactants in cleaning and industrial formulation
Replaces: Petrochemical surfactants in cleaners and formulations - linear alkylbenzene sulfonate (LAS), alcohol ethoxylates (AEO), alkylphenol ethoxylates …
3CHEM
D1Pulp bleaching with xylanase enzyme pre-bleaching and ECF/TCF processes (oxygen, peroxide, ozone) — instead of elemental chlorine bleaching; with biological effluent treatment
Replaces: Elemental chlorine (Cl2) and hypochlorite bleaching of kraft/sulfite pulp; reduces chlorine dioxide demand in ECF
4CHEM

Screened candidates 5

I07detergent enzymes for low-temperature washing instead of phosphates and hot washing
write — from company research 2026-10-06
D3
I08acrylamide by nitrile hydratase enzyme instead of copper-catalysed hydration
drop — Only market-research, company or pilot figures verified — no article without evidence.
D3
I09enzymatic pitch control and deinking in papermaking instead of chemical dispersants and caustic
drop — Only market-research, company or pilot figures verified — no article without evidence.
D1
I10bio-based 1,3-propanediol by fermentation instead of petrochemical acrolein and ethylene-oxide routes
fold into BR01 — Platform chemical.
D2
I11enzymatic fat splitting and enzymatic esterification instead of high-pressure thermal fat splitting and acid or metal catalysts in oleochemicals
drop — from company research 2026-10-06
D1

Technologies 26

Bio all-purpose home cleaners
Household surface, dish and multi-purpose cleaners built on plant-derived surfactants and enzyme stain-removal chemistry rather than petrochemical solvents — …
Enzymes & biocatalysis
Bio-acrylic acid
Renewable routes to acrylic acid, the C3 monomer behind superabsorbent polymers, paints, coatings and adhesives, across two distinct value chains: …
Platform chemicals
Bio-aviation & bio-marine lubricants
Biodegradable ester-based lubricants and greases for marine stern tubes, wire ropes and deck equipment, and bio-based greases for aircraft maintenance — sold by …
Specialty & fine chemicals
Bio-based clean-in-place (bio-CIP)
Enzymatic detergents — protease, lipase, amylase and cellulase blends — that replace or reduce caustic and acid chemistry in clean-in-place (CIP) systems for …
Enzymes & biocatalysis
Bio-based plasticizers
Bio-based plasticizers replace regulated petroleum-derived phthalates (DEHP, DBP, DINP — under EU REACH SVHC and US EPA scrutiny for endocrine-disrupting …
Polymers & materials
Bio-based surface treatment of metals
Rust preventatives, VCI films, epoxy coatings and lignin-based coatings formulated with bio-based oils, resins or lignin instead of fully petrochemical …
Specialty & fine chemicals
Bio-corrosion inhibition
Plant-derived and biodegradable corrosion inhibitors — VpCI vapor-phase additives, anaerobically biodegradable VCI packaging films and bio-based cooling-water …
Specialty & fine chemicals
Bio-degreasing
Replacing chlorinated-solvent and petroleum-based degreasers with lipase enzymes and living microbial cultures that continuously digest oil and grease inside …
Enzymes & biocatalysis
Biocatalysis in petrochemistry
Replacing energy-intensive metal and chemical catalysts in petrochemical synthesis with engineered enzymes, immobilized flow reactors and cell-free systems — …
Enzymes & biocatalysis
Biosolvents & green solvents
Bio-derived solvents — ethyl lactate from fermented lactic acid (Corbion's Biviture brand, Galactic's Galactic bio-solvents line, Vertec Biosolvents' corn-based …
Specialty & fine chemicals
Biosurfactants
Microbial surface-active glycolipids (rhamnolipids, sophorolipids, MELs) produced by aerobic fermentation of plant oils and sugars — biodegradable, low-toxicity …
Specialty & fine chemicals
Biosynthetic acrylamide (flocculants & bio-acrylamide)
Enzymatic conversion of acrylonitrile to acrylamide via immobilized Rhodococcus rhodochrous cells, replacing copper-catalyzed synthesis for water-treatment, …
Platform chemicals
Biosynthetic butadiene
Renewable routes to 1,3-butadiene, the C4 monomer behind synthetic rubber and ABS plastics, via two competing chemistries: catalytic bioethanol-to-butadiene …
Platform chemicals
Biosynthetic butanol, isobutanol and bio-C4 platforms
Fermentation-derived C4 building blocks — isobutanol, isobutene, n-butanol and gas-fermentation C4 diols — produced as platform intermediates for renewable jet …
Platform chemicals
Biosynthetic ethylene & bio-ethylene oxide
Producing the world's most ubiquitous petrochemical building block from renewable biomass and captured carbon.
Platform chemicals
Biosynthetic Monomers: Succinate, Itaconate, FDCA & BDO
Bio-based platform chemicals — succinic acid, itaconic acid, FDCA, and 1,4-BDO — produced via precision fermentation from C5/C6 sugars, replacing fossil …
Platform chemicals
Biosynthetic specialty & fine chemicals (precision fermentation, biocatalysis, biorefinery)
High-value molecules — flavors, fragrances, food ingredients and bio-based monomers — produced by precision fermentation, biocatalysis and lignocellulose …
Specialty & fine chemicals
Cellulose, fibers & wood chemicals
Industrial-scale cellulosic fiber production — viscose, Lyocell and cellulose acetate spun from wood pulp — that is displacing the toxic CS2 solvent process of …
Cellulose & lignin
Enzymatic polymer synthesis in vitro
Cell-free directed synthesis of high-molecular-weight polymers utilizing purified recombinant enzymes ex vivo, eliminating metabolic constraints to produce …
Enzymes & biocatalysis
Enzyme-based laundry detergents (consumer SKU)
Consumer laundry detergents whose cleaning power rests on a loaded enzyme core — protease and lipase stain removal (Dropps, Ecover), multi-enzyme …
Specialty & fine chemicals
Gas fermentation to chemicals
Acetogenic bacteria fix steel-mill and refinery off-gas (CO, CO2, H2) into recycled-carbon ethanol, acetone and sustainable aviation fuel through the …
Biofuels & bioenergy
Industrial Enzymes & Biocatalysis
Industrial enzymes and biocatalysis replace chemical processes with protein-catalyzed reactions — cutting energy by 40–70%, reagent costs, and waste streams …
Enzymes & biocatalysis
L-lactic acid industrial scale (PLA upstream)
Industrial-scale fermentation of L-lactic acid, the upstream monomer feedstock for polylactic acid (PLA) bioplastics — fermentation scale-up, PLA-integrated …
Platform chemicals
Lignin-derived aromatic chemicals
Depolymerising the lignin fraction of woody biomass into renewable aromatic platform chemicals — vanillin, phenolics, BTX and lignosulfonate dispersants — …
Cellulose & lignin
REACH compliance for bio-chemicals
Regulatory consultancies and compliance-intelligence software that register, classify and monitor bio-based chemicals under the EU's REACH regulation — …
Market access & commercial
Terpenes & terpenoids as platform molecules
Fermentation-derived terpenes and terpenoids — farnesene, limonene, valencene, squalane — replacing petrochemical and plant-extracted equivalents in cosmetics, …
Platform chemicals

Opportunities 2