# Downstream & purification equipment — Downstream purification & bioseparation (DSP)

Downstream — separation & purification — Downstream processing (DSP) turns a raw bioreactor harvest into a clinical-grade drug substance — chromatography (Protein A, IEX, HIC), tangential-flow filtration and viral clearance make up over 50% of biomanufacturing capital cost. The global DSP market exceeds $5B and is growing at over 8% a year.

Source: https://en.bioecon.ru/market/downstream/downstream-purification-bioseparation/