technology

Continuous crystallization

Plug-flow or mixed-suspension-mixed-product-removal crystallizers that run at steady state under ICH Q13, replacing batch crystallizers for high-volume APIs with tighter particle-size distribution and smaller footprint.

Where it's used

Crystallization equipment for pharmaceutical APIs
The stirred, draft-tube-baffled, melt and continuous crystallizers — plus the inline FBRM/PVM probes that close the loop on them — that turn a purified API molecule into a defined polymorph with a target particle-size distribution, the unit operation on which bioavailability, purity and downstream filterability all depend.
downstream-purification 7 min