technology

Fixed-bed perfusion bioreactor

Cells grow attached to a fixed matrix bed through which media flows continuously, decoupling cell density from the mixing-shear constraints of a suspension culture.

Where it's used

High-cell-density culture systems
Bioreactor hardware engineered to sustain far higher viable-cell densities than a conventional stirred tank — Repligen's XCell ATF perfusion system (100M+ cells/mL), PBS Biotech's Vertical-Wheel bioreactors, Univercells Technologies' scale-X fixed-bed platform, and Cellexus's CellMaker airlift bioreactors — the equipment layer that lets a fed-batch or perfusion process pack more cells and more product into the same reactor volume.
upstream-bioreactors 8 min