technology

Melt crystallization

Purification by fractional freezing of a melt rather than from solvent, exploiting small impurity partition coefficients to reach electronic- or pharma-grade purity without solvent handling.

Where it's used

Crystallization equipment for pharmaceutical APIs
The stirred, draft-tube-baffled, melt and continuous crystallizers — plus the inline FBRM/PVM probes that close the loop on them — that turn a purified API molecule into a defined polymorph with a target particle-size distribution, the unit operation on which bioavailability, purity and downstream filterability all depend.
downstream-purification 7 min