technology

Process intensification

Raising volumetric productivity of a bioreactor through high cell-density perfusion (alternating tangential-flow filtration, ATF), concentrated feeds and higher power-per-volume, so a 2000 L single-use reactor matches the output of a much larger stainless vessel.

Where it's used

Single-use bag bioreactors (50L-2000L)
Gamma-irradiated single-use bag bioreactors in the 50-2000 L stirred-tank class — Sartorius Biostat STR, Cytiva Xcellerex XDR, Thermo Fisher HyPerforma, Merck Mobius — that replaced stainless steel for clinical and commercial mAb, vaccine and cell-and-gene-therapy manufacturing, cutting facility build-out from years to weeks and underpinning the CDMO economy.
upstream-bioreactors 10 min