Technology · Synbio & enabling tech / Genome engineering

CRISPR gene-editing therapies (Casgevy)

Ex-vivo editing of a patient's stem cells with CRISPR-Cas9, as in Casgevy for sickle cell disease and beta-thalassemia — approved by the FDA, MHRA, EMA and Health Canada in 2023–2024 and replacing regular blood transfusions.

Maturity 8/9 Risk: high Advanced therapies US · EU verified 2026-10-16 · 4 Sources

1 · What it gives

CRISPR gene editing modifies genetic material precisely and in a targeted way. Casgevy (exagamglogene autotemcel) is the commercial example: patient stem cells are harvested, edited ex vivo with CRISPR-Cas9, the patient receives chemotherapy and the edited cells are reintroduced. It replaces the need for regular blood transfusions in severe beta-thalassemia and sickle cell disease. It received regulatory approvals in 2023 and 2024.

2 · What it replaces 6

D0	Bacteriophage therapy for bacterial disease in fish and shrimp farming instead of medicated-feed antibiotics Replaces: Antibiotics in medicated feed and bath treatments - oxytetracycline, florfenicol, oxolinic acid, enrofloxacin, sulfonamide-trimethoprim …	VET
D2	Crop disease forecasting models, spore traps, pheromone and smart pest traps and field diagnostics — spray when risk is real instead of calendar-based fungicide and insecticide programmes Replaces: Fixed-interval ("calendar") protective fungicide sprays and routine insecticide applications regardless of pest pressure	EAC
D1	Enteric methane from cattle and sheep reduced by bromoform-containing red seaweed (Asparagopsis), essential-oil and plant-extract feed additives, and low-methane genetics — instead of unabated emissions and synthetic inhibitors alone Replaces: Unabated enteric methane; reliance on the synthetic inhibitor 3-nitrooxypropanol (3-NOP) as the only approved tool; ionophore antibiotics …	FEED
D2	Industrial biocatalysis (enzymes and whole cells) — e.g. nitrile hydratase for acrylamide, engineered transaminase for sitagliptin, enzymatic antibiotic side-chain processes — instead of heavy-metal catalysts, high-pressure hydrogenation and multistep chemistry with toxic reagents Replaces: Copper-catalysed sulfuric-acid hydration of acrylonitrile; rhodium-catalysed high-pressure asymmetric hydrogenation; chemical deacylation of …	CHEM
D3	Insect-resistant (Bt) crop varieties — cotton, maize, soybean, eggplant — instead of broad-spectrum insecticide sprays against bollworms, stem borers and fruit borers Replaces: Repeated organophosphate, carbamate and pyrethroid sprays against lepidopteran pests (Helicoverpa, pink bollworm, Ostrinia/Sesamia corn …	GM
D2	Mosquito and blackfly control with Bacillus thuringiensis israelensis (Bti) and Lysinibacillus sphaericus larvicides, source reduction, and plant-based repellents — instead of organophosphate larvicides and pyrethroid space fogging Replaces: Temephos and other organophosphate larvicides (fenthion, chlorpyrifos, malathion), pyrethroid/OP ULV fogging (deltamethrin, cypermethrin, …	BIOCIDE

3 · How to implement 4 steps

1
Harvest cells
Harvest the patient’s stem cells.
2
Edit ex vivo
Edit them ex vivo with CRISPR-Cas9.
3
Condition the patient
Give the patient chemotherapy (myeloablative conditioning).
4
Reinfuse
Reintroduce the edited cells.

4 · Who delivers

Matched suppliers (matched automatically)

Huazhi Rice Gene Technology	China	Not classified	active
Shandong Shunfeng Biotechnology	China	Producer	active
Kheiron Biotech	Argentina	Not classified	active
AGseed	Argentina	Research / RTO	active
ALBORS SRL \| Animal Health & Welfare	Italy	Research / RTO	active
Absolute	India	Not classified	active
Acceligen	United States	Not classified	active
Agricultural Research Center (ARC Egypt)	Egypt	Research / RTO	active
Agricultural Research Council (ARC)	South Africa	Research / RTO	active
Alliance of Bioversity International and CIAT	Colombia	Research / RTO	active
Arauco (Bioforest)	Chile	Research / RTO	active
BNARI-GAEC	Ghana	Research / RTO	active

Leading companies and institutes (from the brief)

Vertex Pharmaceuticals and CRISPR Therapeutics are named as the companies that developed and deliver Casgevy. Others are matched by the portal under Advanced therapies.

5 · Rules & route to market

Route into Russia / EAEU: VET · Rosselkhoznadzor
155-235 working days under EAEU rules (plus dossier); national 61-FZ route open until 31.12.2027
Information, not legal advice — confirm the procedure for your product. (2026-10-06)

United States

Casgevy is approved by the US FDA.

European Union

Casgevy is approved by the European Medicines Agency, the UK MHRA and Health Canada.

China

The sources reviewed on 2026-10-16 identified no China regulator or standard specific to this technology. Treat the route as case-by-case and ask for a check.

6 · Money: tenders & grants

Tender	Austria – Laboratory, optical and precision equipments (excl. glasses) – Vollautomatisches Automated Liquid … Kepler Universitätsklinikum GmbH · Austria	Oct 19, 2026 3 days
Tender	Bulgaria – Biochemical analysers – Доставка на анализатор на влага АЕЦ КОЗЛОДУЙ ЕАД · BGR	Oct 19, 2026 3 days
Tender	Czechia – Blood-testing reagents – Dodávky spotřebního materiálu s výpůjčkou analyzátorů krevních plynů Karlovarská krajská nemocnice a.s. · Czechia	Oct 19, 2026 3 days
Tender	Czechia – Mass spectrometer – Dodávka plynového chromatografu s hmotnostním spektrometrem typu trojitý … Fakultní nemocnice Plzeň · Czechia	Oct 22, 2026 6 days
Tender	Czechia – Mass spectrometer – UPOL/PřF/KOCH - Vysokorozlišující hmotnostní spektrometr typu Q-ToF Univerzita Palackého v Olomouci · Czechia	Oct 19, 2026 3 days
Tender	France – Biomedical equipment – Fourniture, installation, mise en service, consommables captifs et maintenance … CHU de Dijon Bourgogne · France	Oct 19, 2026 3 days
Tender	France – Detection and analysis apparatus – Fourniture d’un chromatogramme en phase liquide couplé à un … CEA Grenoble · France	Oct 19, 2026 3 days
Tender	France – Spectrometers – Acquisition d’un spectromètre de résonance magnétique nucléaire de paillasse pour le … CNRS Délégation Alsace · France	Oct 21, 2026 5 days
Tender	France – Spectrum analyser – Acquisition, installation et mise en service d’un ellipsomètre spectroscopique … CNRS Délégation Régionale Hauts-de-France · France	Oct 19, 2026 3 days
Tender	France – Vibration analysers – 2026FOUR014MLV Université Gustave Eiffel · France	Oct 19, 2026 3 days
Tender	Germany – Chromatographs – Fraunhofer ITMP München PR1287581- Ultra-High-Performance-Liquid-Chromatography- … Fraunhofer ITEM · Germany	Oct 19, 2026 3 days
Tender	Germany – Spectrometers – MICADO Integral Field Unit II Max-Planck-Institut für extraterrestrische Physik (MPE) · Germany	Oct 20, 2026 4 days
Tender	Greece – Biochemical analysers – ΗΛΕΚΤΡΟΝΙΚΟΣ ΑΝΟΙΚΤΟΣ ΔΙΑΓΩΝΙΣΜΟΣ ΑΝΩ ΤΩΝ ΟΡΙΩΝ ΣΕ ΕΥΡΩ ΓΙΑ ΤΗΝ ΠΡΟΜΗΘΕΙΑ … ΓΕΝΙΚΟ ΑΝΤΙΚΑΡΚΙΝΙΚΟ ΟΓΚΟΛΟΓΙΚΟ ΝΟΣΟΚΟΜΕΙΟ ΑΘΗΝΩΝ "Ο ΑΓΙΟΣ ΣΑΒΒΑΣ" · Greece	Dec 11, 2026 56 days
Tender	Greece – Gas-detection apparatus – Δ8499 ΕΤΑΙΡΙΑ ΥΔΡΕΥΣΕΩΣ ΚΑΙ ΑΠΟΧΕΤΕΥΣΕΩΣ ΠΡΩΤΕΥΟΥΣΗΣ Α.Ε. (Ε.ΥΔ.Α.Π. Α.Ε.) · Greece	Nov 4, 2026 19 days
Tender	Italy – Biomedical equipment – GARA EUROPEA A PROCEDURA APERTA, AI SENSI DELL’ART. 71 DEL D.LGS. 36/2023, PER … Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico · Italy	Oct 21, 2026 5 days
Tender	Italy – Mass spectrometer – Fornitura, installazione, assistenza, manutenzione, formazione e garanzia full … DIREZIONE TERRITORIALE PIEMONTE E VALLE D'AOSTA · Italy	Oct 26, 2026 10 days
Tender	Luxembourg – Cytometers – RFP 260039 - TENDER FOR THE ACQUISITION OF A NANO PARTICLE FLOW CYTOMETER SYSTEM AND … UNIVERSITE DU LUXEMBOURG · LUX	Oct 20, 2026 4 days
Tender	Netherlands – Blood-testing reagents – Gevalideerde Totaaloplossing voor de hielprikscreening op … Rijksinstituut voor Volksgezondheid en Milieu (RIVM) · Netherlands	Nov 10, 2026 25 days
Tender	Netherlands – Laboratory, optical and precision equipments (excl. glasses) – Europese Aanbesteding … Leids Universitair Medisch Centrum (LUMC) · Netherlands	Oct 23, 2026 7 days
Tender	Norway – Laboratory, optical and precision equipments (excl. glasses) – Isotope Ratio Mass Spectrometry system Norwegian University of Life Sciences · Norway	Oct 19, 2026 3 days
Tender	Poland – Blood-testing reagents – SUKCESYWNE DOSTAWY ODCZYNNIKÓW HEMATOLOGICZNYCH Z DZIERŻAWĄ 2 ANALIZATORÓW I … Szpitale Pomorskie Sp. z o.o. · Poland	Oct 22, 2026 6 days
Tender	Poland – Chemical reagents – Dzierżawa analizatora do bezpośredniej identyfikacji drobnoustrojów i genów … Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy Oddział w Gliwicach · Poland	Oct 19, 2026 3 days
Tender	Poland – Detection and analysis apparatus – Dostawa 2 szt. inkubatorów CO2 dla Wydziału Biologii UW Uniwersytet Warszawski · Poland	Oct 22, 2026 6 days
Tender	Poland – Laboratory glassware – 103.2026 Sukcesywna dostawa drobnego sprzętu laboratoryjnego na potrzeby … Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu · Poland	Oct 19, 2026 3 days
Tender	Poland – Laboratory reagents – (DFP.271.175.2026.PS) Dostawa odczynników, materiałów zużywalnych wraz z … SZPITAL UNIWERSYTECKI W KRAKOWIE · Poland	Oct 20, 2026 4 days
Tender	Poland – Laboratory reagents – Dostawa odczynników do oznaczeń biochemicznych z najmem analizatora na okres 48 … Samodzielny Publiczny Szpital Kliniczny im. Prof. A. Grucy CMKP · Poland	Oct 19, 2026 3 days
Tender	Poland – Spectrometers – ZP/84/2026 Rozbudowa systemu LC-MS w ramach projektu ”CLEAN ROOM- laboratorium … Uniwersytet Medyczny w Łodzi · Poland	Oct 19, 2026 3 days
Tender	Romania – Biochemical analysers – Achiziționarea unui sistem automat de identificare microbiană prin metoda … SPITALUL CLINIC FILANTROPIA · Romania	Oct 20, 2026 4 days
Tender	Romania – Gas-detection apparatus – Detectoare de gaze, incluzând accesorii și serviciile de mentenanță … DISTRIGAZ SUD RETELE S.R.L. · Romania	Oct 19, 2026 3 days
Tender	Spain – Mass spectrometer – El suministro, instalación, puesta en marcha y formación de un sistema de … Fundación BCMaterials - Basque Center for Materials, Applications and Nanostructures - Fundación BCMaterials · Spain	Oct 18, 2026 2 days
Grant	Health of ecosystems and wild species, predictions and impacts on human health, in the face of existing and … European Commission · EU	Sep 22, 2027 341 days
Grant	Microbiome for terrestrial livestock sustainability and health within a One Health approach European Commission · EU	Sep 23, 2027 342 days
Grant	Advancing Global Health Bureau of Global Health Security and Diplomacy · United States	Feb 14, 2027 121 days
Grant	Advancing bio-printing of living cells for regenerative medicine European Commission · EU	Sep 22, 2027 341 days
Grant	DOD Defense Health Agency (DHA) Research & Development FY23-FY27 BROAD AGENCY ANNOUNCEMENT for Extramural … Defense Health Agency Contracting Activity - DHACA · United States	Sep 30, 2027 349 days

7 · Tech stack & innovations

Main risks from the sources: off-target gene modifications, uncertain long-term safety, and the potential need for myeloablative conditioning.

Sources 4

Cell.com — www.cell.com 2026-10-16
Nice.org.uk — www.nice.org.uk 2026-10-16
Ir.crisprtx.com — ir.crisprtx.com 2026-10-16
Ncbi.nlm.nih.gov — www.ncbi.nlm.nih.gov 2026-10-16