Technology · Agri-food systems / Livestock & aquaculture

Feed-antibiotic replacement biologics

Biological substitutes for subtherapeutic antibiotic growth promoters in feed — commercial in China with over 211,700 tonnes applied by 2017, under the 2021–2025 national action plan to cut veterinary antibiotic use.

Maturity 8/9 Risk: medium Feed Veterinary CN · EU verified 2026-10-16 · 4 Sources

1 · What it gives

These biological substitutes replace conventional subtherapeutic antibiotic growth promoters used in feed for growth promotion and disease prevention. The sector is at commercial scale: over 211,700 tonnes of products were applied in China by 2017.

2 · What it replaces 6

D2	Poultry gut health without antibiotic growth promoters and colistin — competitive exclusion cultures, Bacillus probiotics and bacteriophages Replaces: In-feed antibiotic growth promoters (bacitracin, avilamycin, tylosin, virginiamycin, flavomycin), prophylactic colistin, enrofloxacin and …	FEED
D2	Yeast cell-wall (MOS/β-glucan), nucleotide and postbiotic additives instead of the antibiotic-growth-promoter era's ingredient logic Replaces: The AGP-era program of routine "tonnage" additives: subtherapeutic antibiotics (banned — V01), high zinc/copper growth doses (phasing out), …	FEED
D2	Cassava mealybug classical biological control with Anagyrus lopezi instead of insecticides Replaces: Insecticide spraying (rarely affordable for smallholders) and uncontrolled crop losses from the invasive cassava mealybug in Africa	CLASSIC
D2	On-farm culture, PCR panels, rapid tests and veterinary laboratory services for livestock and aquaculture — treat what is diagnosed instead of blanket and prophylactic antibiotic treatment Replaces: Blanket treatment of every clinical mastitis case, group metaphylaxis on suspicion, prophylactic antibiotics in hatcheries and ponds, …	DIAG
D2	Dairy mastitis prevention with selective dry-cow therapy, internal teat sealants and bacteriocin (nisin) teat disinfection Replaces: Blanket dry-cow antibiotic therapy (all quarters, all cows: cloxacillin, cephalosporins incl. 3rd/4th generation, penicillin–aminoglycoside …	VET
D2	Enhanced biological phosphorus removal instead of chemical precipitation with metal salts Replaces: Chemical phosphorus precipitation with ferric chloride, ferrous sulfate or aluminium salts in municipal and industrial wastewater treatment	SERV

3 · How to implement 3 steps

1
Consult on approval
Establish regulatory approval consultations.
2
Update declarations
Revise declaration requirements for new additives.
3
Safety and evaluation guidance
Issue safety and evaluation guidelines.

4 · Who delivers

Matched suppliers (matched automatically)

MAYASAN A.S.	Turkey	Producer	active
SONKUL AGRO INDUSTRIES PVT. LTD.	India	Services / consulting	active
BioHAYAT	Turkey	Research / RTO	active
EGAVET	Egypt	Research / RTO	active
Zytex	India	Producer	active
Varsha Bioscience and Technology Private Limited	India	Research / RTO	active
SGTech - Zero Carbon, Sustainable Farming	Israel	Research / RTO	active
Phileo by Lesaffre	France	Producer	active
Nor-Feed	France	Research / RTO	active
3A Austria GmbH	Austria	Producer	active
AABT INDIA PVT LTD	India	Distributor	active
ABESTA	Bangladesh	Distributor	active

Leading companies and institutes (from the brief)

The Feed Research Institute of the Chinese Academy of Agricultural Sciences, Beijing Dabeinong Technology Group and Shandong Baolai-Lilai Bioengineering are named. Others are matched by the portal under Feed.

5 · Rules & route to market

Route into Russia / EAEU: FEED · Rosselkhoznadzor (expertise by VGNKI)
state registration within 45 working days after acceptance of documents (plus dossier and tests)
Information, not legal advice — confirm the procedure for your product. (2026-10-06)

United States

The sources reviewed on 2026-10-16 identified no the US regulator or standard specific to this technology. Treat the route as case-by-case and ask for a check.

European Union

The sources point to EU rules alongside the Chinese plan without naming a specific instrument.

China

Oversight in China is led by the Ministry of Agriculture and Rural Affairs through the National Action Plan for Reducing Veterinary Antibiotic Use (2021–2025).

6 · Money: tenders & grants

Grant	Agriculture and Food Research Initiative Competitive Grants Program Foundational and Applied Science Program National Institute of Food and Agriculture · United States	Dec 31, 2026 76 days
Grant	Strengthening strategic advice and synergies between EU and national Research and Innovation agendas and … European Commission · EU	May 11, 2027 207 days

7 · Tech stack & innovations

The sources reviewed list no verified risks; check efficacy against the antibiotic baseline for your species and ask for a check.

Sources 4

Moa.gov.cn — www.moa.gov.cn 2026-10-16
Pmc.ncbi.nlm.nih.gov — pmc.ncbi.nlm.nih.gov 2026-10-16
Caas.cn — caas.cn 2026-10-16
Openknowledge.fao.org — openknowledge.fao.org 2026-10-16