# Micropeptide plant-protection agents Short peptide and protein biocontrol agents — venom-derived insecticidal peptides, antimicrobial peptide fungicides and defense-elicitor peptides — that protect crops with novel modes of action and favorable non-target safety. Source: https://en.bioecon.ru/technology/micropeptide-plant-protection/ Updated: 2026-09-02 ## Overview and value chain Markers: [EC: Farm to Fork & Sustainable Use Regulation | OECD: Agricultural Biotechnology | Regulator: EPA (USA), EFSA (EU), MoA (China)] Micropeptide plant-protection agents are short peptides and proteins applied to crops to control pests and diseases through novel, biodegradable modes of action. Three mechanistic families dominate: cysteine-rich insecticidal peptides derived from spider venoms that disrupt insect ion channels (Vestaron SPEAR and BASIN, the latter EPA-approved for outdoor crops in February 2026); antimicrobial peptides that rupture fungal cell membranes (Micropep Promisin, backed by more than 200 field trials); and signaling peptides that switch on the plant's own systemic acquired resistance (PI AgSciences PHC68949, the first foliar-applied peptide active ingredient against parasitic nematodes, EPA-registered in March 2026). The category is moving from niche to mainstream as Vestaron's flagship SPEAR LEP is already used on more than 1 million acres, and Biotalys projects the Botrytis and powdery-mildew segment targeted by its EVOCA NG biofungicide at roughly USD 1.1 billion. Unlike chemical synthetics, peptide active ingredients carry MRL exemptions and degrade rapidly in the field, which underpins their favorable pollinator and beneficial-insect profile. The key directions of micropeptide plant protection are: 1. **Insecticidal venom peptides (Insecticidal Venom Peptides):** cysteine-rich peptides from spider venoms targeting lepidopteran and soft-bodied pests, now EPA-registered and deployed on more than 1 million acres. 2. **Antimicrobial peptide biofungicides (Antimicrobial Peptide Biofungicides):** short membrane-disrupting peptides controlling fungal diseases such as Asian Soybean Rust, with first regulatory dossiers filed in 2026. 3. **Defense-activator peptides (Defense-Activator Peptides):** signaling peptides that trigger systemic acquired resistance, delivering the first foliar peptide nematicide and a registered tool against citrus greening. 4. **AI-driven peptide discovery (AI-Driven Peptide Discovery):** platforms such as Krisalix and DNA-encoded libraries that computationally design short, target-specific peptide structures before synthesis. ### Sectoral value chain ``` [peptide discovery] ──> [sequence design] ──> [production] ──> [formulation] │ (novel mode of action) │ ▼ [pest / disease control] <─── [field spray] <─────┘ ``` ### Value chain levels | Level | Description | Key inputs/outputs | |:---|:---|:---| | **Peptide Discovery** | mine venoms, genomes or AI libraries for lead peptides | **In:** venom/gene databases, AI models. **Out:** candidate peptides. | | **Sequence Design** | engineer disulfide scaffolds, screen off-targets | **In:** structural biology, bioinformatics. **Out:** optimized sequence. | | **Production** | recombinant expression in yeast or microbial fermentation | **In:** host strains, media. **Out:** bulk peptide. | | **Formulation** | stabilize against UV and rain, add adjuvants | **In:** stabilizers, carriers. **Out:** sprayable product. | | **Registration** | EPA FIFRA biochemical, EFSA, MoA review | **In:** efficacy and safety dossiers. **Out:** commercial label. | | **Field Application** | foliar spray integrated into IPM rotations | **In:** sprayer, label rate. **Out:** protected crop. | Cross-cutting technologies of the sector: - **Cysteine-rich disulfide scaffolds (Cysteine-Rich Disulfide Scaffolds):** constrained peptide backbones that resist proteolysis and confer insecticidal potency. - **Recombinant microbial expression (Recombinant Microbial Expression):** yeast and E. coli secretion of bioactive peptides at field-relevant cost. - **AI peptide design engines (AI Peptide Design Engines):** predictive platforms that generate short peptide structures against a chosen pest or pathogen target. --- ## US The US leads the category on regulatory firsts, with three peptide active ingredients EPA-registered within a single year and a deep precision-biology discovery base. ### EPA biochemical registrations, venom-peptide insecticides, defense-activator nematicides - **Vestaron BASIN approval:** the EPA approved BASIN, a modified spider-venom peptide, for outdoor crops in February 2026 — the company's second novel mode of action in six years — controlling lepidopteran pests and soft-bodied insects with an MRL exemption. - **PI AgSciences PHC68949:** the EPA granted federal registration in March 2026 to the first foliar-applied peptide active ingredient against parasitic nematodes, built on the PREtec peptide platform and already commercialized in Brazil and Mexico. - **Elemental Enzymes Strakor:** launched with UPL in May 2026 as the only registered product in Brazil for citrus greening (HLB), using Vismax signaling peptides that activate the plant's systemic immune response. - **AI and encoded-library discovery:** US platforms combine DNA-encoded chemical libraries and structural biology to shorten peptide discovery lead time, partnering with incumbent agchem firms. --- ## CN China couples strong academic antimicrobial-peptide research with a fast-growing biological crop-protection market that MARA registers under its biopesticide track. ### defensin-like AMPs, academic pest-control targets, biopesticide registration - **Defensin-like antimicrobial peptides:** Southwest University (Wang Jinjun and Dou Wei labs) characterized novel defensin-like antimicrobial peptides as control agents for Bactrocera dorsalis (Pest Management Science, 2026). - **Engineered immunoproteins:** Chinese groups publish rationally concatenated peptide chimeras (for example 151-amino-acid RP151) that induce broad-spectrum disease resistance in solanaceous crops within 24 hours. - **MARA biopesticide track:** the Ministry of Agriculture registers peptide and protein products alongside microbial and botanical biopesticides, without a standalone biochemical category. - **Market outlook:** domestic industry reports frame biological crop protection as the principal growth substitute as high-toxicity chemical pesticides are phased out. --- ## EU The EU frames peptide biocontrol as a core instrument of its Farm to Fork target to halve chemical pesticide use by 2030, with EFSA assessing protein active ingredients under its biocontrol risk framework. ### Farm to Fork biocontrol, EFSA protein assessment, Krisalix discovery - **Farm to Fork push:** the 50% chemical-pesticide reduction target by 2030 positions species-specific peptide biocontrol as a key substitute in IPM programs. - **Biotalys EVOCA EU pathway:** the Dutch CTGB recommended EU-wide approval of the AGROBODY protein biofungicide EVOCA for Botrytis and powdery mildew, the first such recommendation for a protein-based biocontrol. - **Krisalix discovery engine:** Micropep Technologies (Toulouse) uses its AI-driven Krisalix platform to design the short antimicrobial peptide behind Promisin, its lead biofungicide. - **EFSA risk assessment:** EU frameworks evaluate environmental fate and non-target effects of peptide and protein active ingredients, requiring sequence-level off-target screening. --- ## Leading companies and research institutes | Company / Institute | Country | Key products / platforms | Tech features | Status 2026 | |:---|:---|:---|:---|:---| | **Vestaron** | 🇺🇸 USA | *SPEAR LEP, BASIN* | modified spider-venom peptide bioinsecticides, EPA-registered | Commercial | | **PI AgSciences** | 🇺🇸 USA | *PHC68949 (PREtec)* | peptide defense-activator (SAR), first foliar peptide nematicide | Commercial | | **Elemental Enzymes** | 🇺🇸 USA | *Strakor (Vismax)* | signaling peptide activating plant immunity, citrus-greening tool | Commercial | | **Biotalys** | 🇧🇪 Belgium | *EVOCA (AGROBODY)* | protein nanobody biofungicide, new FRAC Group 51 | Operating | | **Micropep Technologies** | 🇫🇷 France | *Promisin (Krisalix)* | AI-designed antimicrobial peptide biofungicide | Pilot | | **Southwest University** | 🇨🇳 China | *defensin-like AMPs* | academic antimicrobial-peptide pest-control research | Research | --- ## Tech stack and innovations The stack fuses computational peptide design, recombinant production and protective formulation so that a short peptide can survive from lab bench to field canopy. 1. **AI-driven peptide design (AI-Driven Peptide Design):** - the Krisalix engine generates short, target-specific peptide structures against plant pathogens and pests using predictive modeling. - DNA-encoded libraries and structural biology shorten the discovery-to-lead cycle, with safety guardrails built in early. 2. **Recombinant peptide production (Recombinant Peptide Production):** - cysteine-rich insecticidal peptides are expressed in yeast secretion systems that preserve the disulfide scaffold required for activity. - microbial fermentation collapses the cost ceiling that historically kept peptide crop protection academic. 3. **Stabilization and formulation (Stabilization and Formulation):** - disulfide-constrained scaffolds and formulation chemistry protect peptides from UV, rain and proteolytic degradation. - tank-mix compatibility and foliar uptake adjuvants let peptide products rotate with conventional chemistry in existing spray programs. --- ## Value chains and production pipelines ### Industrial pipeline of a peptide biocontrol product (EPA FIFRA biochemical pesticide) ``` ┌───────────────────────────┐ ┌───────────────────────────┐ │ 1. Peptide discovery │ ───> │ 2. Sequence design │ └───────────────────────────┘ └───────────────────────────┘ │ ▼ ┌───────────────────────────┐ ┌───────────────────────────┐ │ 4. Formulation │ <─── │ 3. Recombinant production │ └───────────────────────────┘ └───────────────────────────┘ │ ▼ ┌───────────────────────────┐ ┌───────────────────────────┐ │ 5. Registration & safety │ ───> │ 6. Field application │ └───────────────────────────┘ └───────────────────────────┘ ``` #### Stage 1: Peptide discovery Venom glands, pathogen genomes and AI libraries are mined for lead peptides whose mode of action is lethal to the target pest or pathogen. #### Stage 2: Sequence design Structural biology and bioinformatics engineer disulfide scaffolds and optimize the sequence while screening against non-target species to limit off-target effects. #### Stage 3: Recombinant production Yeast secretion or microbial fermentation expresses the peptide at scale, where cost per gram is the binding economic constraint for field use. #### Stage 4: Formulation Stabilizers, UV screens and adjuvants protect the peptide from environmental degradation and improve cuticular and leaf uptake. #### Stage 5: Registration and safety review Agencies assess efficacy, environmental fate and non-target safety under the biochemical pesticide track; the EPA registered BASIN in February 2026 and PHC68949 in March 2026. #### Stage 6: Field application The formulated peptide is foliar-sprayed and integrated into IPM rotations, where its novel mode of action delivers resistance management and a favorable pollinator and beneficial-insect profile.