Technology · Health & biomedicine / Therapeutics & platforms

Multivalent & combination vaccines

Vaccines that protect against several diseases in one injection — quadrivalent and pentavalent products are on the market in China, with 310,000 and 790,000 doses released in 2022 from two named suppliers.

Maturity 8/9 Risk: medium Pharma & biologics CN verified 2026-10-16 · 4 Sources

1 · What it gives

Multivalent and combination vaccines combine several vaccines, or vaccines with toxoids, in set proportions so one injection prevents multiple diseases. They replace the need for several separate monovalent vaccines. Quadrivalent and pentavalent vaccines are available at commercial scale in China, where lot-release data is tracked annually: in 2022 Beijing Minhai released 310,000 doses of its quadrivalent vaccine and Sanofi Pasteur 790,000 doses of its pentavalent vaccine.

2 · What it replaces 6

D2	Disease-resistant crop varieties (marker-assisted breeding, stacked resistance genes, cisgenesis) instead of routine fungicide spray programmes Replaces: Season-long protective fungicide programmes on susceptible varieties — e.g. 10–20 sprays of mancozeb/chlorothalonil/metalaxyl against potato …	SEED
D1	Garden, allotment and lawn pest control with beneficial nematodes — Phasmarhabditis against slugs, Steinernema/Heterorhabditis against vine weevil, chafer grubs, leatherjackets — instead of metaldehyde pellets and soil insecticides Replaces: Metaldehyde slug pellets (banned outdoors in Great Britain from 2022), methiocarb pellets (EU non-renewed), soil insecticides in gardens and …	MACRO
D1	Disease-resistant livestock genetics — genomic selection, adapted breeds, gene-edited PRRS-resistant pigs — instead of routine antibiotics, acaricides and repeated mass treatment Replaces: Metaphylactic antibiotics used against secondary infections after PRRS and other viral diseases; frequent acaricide dipping of …	BREED
D2	Drone release of beneficial insects (Trichogramma, Cotesia, predatory mites) instead of insecticide sprays Replaces: Insecticide sprays against caterpillar and mite pests, and manual walking release of natural enemies (the labour bottleneck of large-scale …	MACRO
D1	Fermentation (stainless and single-use bioreactors, solid-state reactors) and downstream equipment (centrifuges, filtration, spray and fluid-bed drying, formulation) for local production of enzymes, microbial products and fermentation ingredients instead of chemical-synthesis plants and imports Replaces: Chemical-synthesis routes and imports for the products in FI-, FD-, I- and A-series articles (enzymes, organic acids, vitamins, microbial …	EAC
D1	Food and market organic waste treated by black soldier fly (BSF) larvae, composting and bokashi fermentation instead of landfilling, open dumping and incineration of wet waste Replaces: Landfilling and open dumping of food/market waste (methane, leachate, vectors); incineration of high-moisture organic waste; chemical fly …	SERV

3 · How to implement 4 steps

1
Laboratory research
Start with laboratory research.
2
Process development
Develop the process.
3
Manufacturing and preclinical
Manufacture the product and run preclinical studies.
4
Clinical trials and evaluation
Run clinical trials and the final safety and efficacy evaluation.

4 · Who delivers

Matched suppliers (matched automatically)

Vaxxinova Norway	Norway	Not classified	active
EGAVET	Egypt	Research / RTO	active
MSD Animal Health Poultry and Swine Sub Sahara Africa	South Africa	Services / consulting	active
Biocamp Laboratórios Ltda	Brazil	Research / RTO	active
Liselo Labs	South Africa	Research / RTO	active
Abtec	India	Research / RTO	active
EcoFix Kenya Ltd (EFK)	Kenya	Producer	active
PT. Central Proteina Prima, Tbk	Indonesia	Producer	active
Vland Biotech 蔚蓝生物 (SSE 603739)	China	Research / RTO	active
A.VET SU ÜRÜNLERİ	Turkey	Not classified	active
AGRIVIET JSC	Vietnam	Services / consulting	active
Aristogene Biosciences Pvt. Ltd.	India	Producer	active

Leading companies and institutes (from the brief)

Beijing Minhai Biotechnology and Sanofi Pasteur are named as providers of quadrivalent and pentavalent vaccines in China.

5 · Rules & route to market

Route into Russia / EAEU: SEED · Ministry of Agriculture (State Register) / State Variety Commission (Gossortkomissia, trials)
2-3 seasons of state variety trials
Information, not legal advice — confirm the procedure for your product. (2026-10-06)

United States

The sources reviewed on 2026-10-16 identified no the US regulator or standard specific to this technology. Treat the route as case-by-case and ask for a check.

European Union

The sources reviewed on 2026-10-16 identified no the EU regulator or standard specific to this technology. Treat the route as case-by-case and ask for a check.

China

In China the NMPA governs vaccine registration, manufacturing and distribution, including recent rules that allow commissioned manufacturing for combination vaccines.

6 · Money: tenders & grants

Tender	Czechia – Immunosuppressive agents – Selektivní Imunosupresiva - Eculizumab IV. Institut klinické a experimentální medicíny · Czechia	Oct 20, 2026 4 days
Tender	Czechia – Immunosuppressive agents – Takrolimus 1x denně - LP ADVAGRAF Institut klinické a experimentální medicíny · Czechia	Oct 20, 2026 4 days
Tender	Netherlands – Influenza vaccines – Trivalent Influenza Vaccines 2026 Rijksinstituut voor Volksgezondheid en Milieu (RIVM), RIVM · Netherlands	Oct 19, 2026 3 days
Grant	Enhancing ecodesign and circularity of construction products European Commission · EU	Sep 22, 2027 341 days
Grant	Replacing hazardous substances in biocidal products European Commission · EU	Sep 22, 2027 341 days
Grant	Strengthening evidence-based policies for the resilience of European agriculture and forestry and related … European Commission · EU	Sep 23, 2027 342 days
Grant	Technical innovation to protect ecosystems and to scale up their restoration European Commission · EU	Sep 22, 2027 341 days

7 · Tech stack & innovations

Main risks from the sources: antigenic interference, high development and clinical cost, regulatory complexity, and interdependence in the manufacturing supply chain.

Sources 4

21jingji.com — www.21jingji.com 2026-10-16
Pmc.ncbi.nlm.nih.gov — pmc.ncbi.nlm.nih.gov 2026-10-16
Vaxlab.dukekunshan.edu.cn — vaxlab.dukekunshan.edu.cn 2026-10-16
Cdn.who.int — cdn.who.int 2026-10-16