Technology · Health & biomedicine / Diagnostics & medtech
One Health — zoonosis & AMR monitoring as a service
Outsourced One Health surveillance that fuses veterinary, human and environmental sampling with shotgun metagenomic sequencing, CARD resistome profiling and AI spillover-risk scoring to detect zoonotic pathogens and antimicrobial resistance, delivered as an ISO 17025 reference-lab service under EU 2003/99/EC, US NARMS and China's containment plan.
1 · What it gives
One Health zoonosis and antimicrobial-resistance (AMR) monitoring as a service sells integrated surveillance — human, animal and environmental compartments read together — to governments, food producers and pharma supply chains that cannot run reference labs in-house. The technical core is shotgun metagenomic sequencing of environmental swabs, feces and wastewater: a single weekly run on an MGI DNBSEQ or Oxford Nanopore platform recovers both the resistome (antimicrobial-resistance genes mapped against the CARD database of more than 5,000 reference sequences) and zoonotic pathogens such as H5N1 avian influenza and African swine fever in one assay. The EU harmonises this through Directive 2003/99/EC and Commission Implementing Decision (EU) 2020/1729, which fix the bacterial panels, the indicator organisms and the breakpoints every member state must report annually. The market is consolidating fast: in March 2026 Zoetis agreed to buy Neogen’s animal-genomics business for 160 million USD, folding 5 reference labs and customers in 120-plus countries into a single commercial surveillance network. The synergy is that genomic pathogen detection, resistome profiling and AI spillover-risk scoring share one sample, one sequencing run and one LIMS, so the marginal cost of adding a second hazard to a surveillance contract is close to zero.
The key directions of One Health zoonosis & AMR monitoring are:
- Veterinary reference diagnostics (commercial lab networks): IDEXX and Zoetis run global point-of-care and reference-lab networks; IDEXX reported 3.81 billion USD in FY2024 revenue and in May 2026 extended its Fecal Dx antigen platform to taeniid tapeworms (Taenia, Echinococcus), detecting up to twice as many intestinal parasite infections as fecal flotation alone.
- Harmonised national AMR surveillance (policy service): EFSA’s EU Summary Report and the EARS-Vet network standardise resistance monitoring in zoonotic and indicator bacteria across all member states, with cost-optimised sampling designs (the Belgian livestock programme being a published reference case).
- Metagenomic environmental surveillance (sentinel service): Wageningen Bioveterinary Research and the ALARUM consortium run active One Health surveillance in low- and middle-income countries using long-read nanopore metagenomics on farm manure and wastewater to predict resistance emergence.
- Spillover early-warning at the wildlife-livestock interface: the Friedrich-Loeffler-Institut and the Harbin Veterinary Research Institute operate BSL-3 reference labs tracking avian influenza and African swine fever, feeding national notification systems before cross-species jumps.
Sectoral value chain#
[sampling] ──> [sequencing] ──> [bioinformatics] ──> [risk scoring]
│
(resistome + pathogen)
│
▼
[policy action] <─── [LIMS reporting] <┘
Value chain levels#
| Level | Description | Key inputs/outputs |
|---|---|---|
| Sampling & cold chain | Weekly environmental swabs, feces, wastewater and clinical isolates across compartments | In: farms, abattoirs, clinics, sewersheds. Out: barcoded, cold-chained samples. |
| Wet lab & sequencing | Host-DNA depletion, library prep, shotgun metagenomic or PCR-panel sequencing | In: samples, reagents, MGI/Nanopore flow cells. Out: raw reads, isolate genomes. |
| Bioinformatics | Taxonomic classification, resistome and virulence-gene calling | In: reads, CARD/Kraken2 references. Out: pathogen and AMR-gene profiles. |
| Risk analytics | AI spillover scoring, trend detection, breakpoint comparison | In: profiles, epidemiological metadata. Out: risk scores, alerts. |
| Reporting & accreditation | LIMS dashboards, ISO 17025 reports, regulatory submissions | In: scored results. Out: EFSA/NARMS-format reports. |
| Policy & intervention | Stewardship advice, outbreak response, trade certification | In: reports. Out: containment and antibiotic-use decisions. |
Cross-cutting technologies of the sector:
- Shotgun metagenomic sequencing (untargeted): one library reads every genome in a sample, recovering pathogens and AMR genes without prior knowledge of the target.
- AMR resistome profiling (CARD/AMRFinderPlus): alignment of reads against curated resistance-gene databases to quantify the resistome and its mobile-element context.
- Genomic pathogen surveillance (real-time): isolate and metagenomic sequencing feeding phylogenetic outbreak tracing and trade-relevant typing.
2 · What it replaces 6 · matched by industry
| D2E3 | Poultry gut health without antibiotic growth promoters and colistin — competitive exclusion cultures, Bacillus probiotics and bacteriophages Replaces: In-feed antibiotic growth promoters (bacitracin, avilamycin, tylosin, virginiamycin, flavomycin), prophylactic colistin, enrofloxacin and … | FEED |
| D3E– | New World screwworm eradication by the sterile insect technique instead of insecticide wound treatment Replaces: Routine insecticide treatment of livestock wounds (organophosphates and other larvicides), animal inspection and losses from myiasis | RELEASE |
| D2E– | On-farm culture, PCR panels, rapid tests and veterinary laboratory services for livestock and aquaculture — treat what is diagnosed instead of blanket and prophylactic antibiotic treatment Replaces: Blanket treatment of every clinical mastitis case, group metaphylaxis on suspicion, prophylactic antibiotics in hatcheries and ponds, … | DIAG |
| D2E– | Cattle tick control with the Bm86 anti-tick vaccine, tick-resistant breeds, pasture spelling and entomopathogenic fungi (Metarhizium) Replaces: Frequent acaricide dipping/spraying/pour-on with organophosphates (coumaphos, diazinon, chlorpyrifos), synthetic pyrethroids (cypermethrin, … | VET |
| D2E4 | Crop disease forecasting models, spore traps, pheromone and smart pest traps and field diagnostics — spray when risk is real instead of calendar-based fungicide and insecticide programmes Replaces: Fixed-interval ("calendar") protective fungicide sprays and routine insecticide applications regardless of pest pressure | EAC |
| D2E– | Dairy mastitis prevention with selective dry-cow therapy, internal teat sealants and bacteriocin (nisin) teat disinfection Replaces: Blanket dry-cow antibiotic therapy (all quarters, all cows: cloxacillin, cephalosporins incl. 3rd/4th generation, penicillin–aminoglycoside … | VET |
3 · How to implement 6 steps
- 1Environmental samplingWeekly boot-swabs, litter and feces are collected across the houses of a one-million-bird layer complex, barcoded and cold-chained to preserve nucleic acids for sequencing.
- 2Host-DNA depletionEnzymatic depletion removes avian host DNA so that the bacterial and viral fraction dominates the library, raising the effective sensitivity for low-abundance pathogens and AMR genes.
- 3Metagenomic library preparationFormulation & blendingTagmentation builds shotgun libraries from the depleted extract, with unique dual indices so that dozens of samples are multiplexed on a single flow cell.Who can do this step matched automatically✓ GMP 500 m3“This is a satellite blending, mixing and formulation facility, located at Vashind near Shahapur and dedicated to the company’s Animal Nutrition business.”India Glycols (NSE) India✓ GMP 7,500 MT/ industrial scale“Recent expansions and new facilities across процесses: MEG production growth (up to 200,000 MTPA), EO purification, ethoxylate, sulphation, formulation plants, and …”
- 4Shotgun sequencingTesting & analyticsLibraries are sequenced on an MGI DNBSEQ or Oxford Nanopore device; a single weekly run recovers both the resistome and zoonotic agents such as H5N1 in one untargeted assay.Who can do this step matched automaticallyBloomage Biotechnology China✓ GMP 320 tons industrial scale“The company positions MitoEGT® as a mitochondria-targeting anti-aging ingredient with multiple efficacy studies, 38 patents, national metrology recognition, and plans to broaden …”Esco Aster Singapore5,000 L industrial scale“Esco Aster (Singapore) is a cGMP contract research, development and manufacturing organization (CRDMO/CDMO) and bioinnovation venture accelerator that helps clients and …”✓ GMP industrial scale“ProBio: A global CRDMO (contract research, development, and manufacturing organization) providing end-to-end solutions for biologics and cell and gene therapy (CGT).”Vaxxinova Norway Norwayindustrial scale“Vaxxinova develops, produces and markets a wide range of innovative vaccines and diagnostic services to protect livestock and fish against diseases.”
- 5Bioinformatic callingData, software & automationReads are classified in Kraken2 and aligned against the CARD database of 5,000-plus resistance references, producing a taxonomic profile, a resistome and virulence-gene calls.Who can do this step matched automatically✓ GMP industrial scale“The two parties will conduct extensive cooperationin the fields of digital agriculture, intelligent breeding and planting,precision feeding, manure treatment, animal disease …”N.Thing South Koreaindustrial scale“Established in January 2014, N.THING is a Seoul-based Agri-Food tech company leading innovation in agricultural products, by extension, in the farm-to-table food value chain by …”UMITRON (SG subsidiary) Singapore“Founded in 2016 and based in Singapore and Japan, UMITRON builds user-friendly aquaculture data platforms that leverage the use of state of the art technologies such as IoT, AI and …”163,050 tonnes“As the fundamental component of 5G deployment, optic fibre is critical to making Hong Kong a smart city and laying the groundwork for IoT.”Stellapps India240,000 liters/day“It leverages advanced analytics and artificial intelligence through its full-stack IoT platform to enable dairy ecosystem partnerships with financial & insurance institutions, …”
- 6Risk scoring and alertData, software & automation
An AI model scores spillover risk and resistance trends, and the accredited LIMS issues EFSA/NARMS-format alerts to operators and competent authorities for stewardship and outbreak response.
Who can do this step matched automatically✓ GMP industrial scale“The two parties will conduct extensive cooperationin the fields of digital agriculture, intelligent breeding and planting,precision feeding, manure treatment, animal disease …”N.Thing South Koreaindustrial scale“Established in January 2014, N.THING is a Seoul-based Agri-Food tech company leading innovation in agricultural products, by extension, in the farm-to-table food value chain by …”UMITRON (SG subsidiary) Singapore“Founded in 2016 and based in Singapore and Japan, UMITRON builds user-friendly aquaculture data platforms that leverage the use of state of the art technologies such as IoT, AI and …”163,050 tonnes“As the fundamental component of 5G deployment, optic fibre is critical to making Hong Kong a smart city and laying the groundwork for IoT.”Stellapps India240,000 liters/day“It leverages advanced analytics and artificial intelligence through its full-stack IoT platform to enable dairy ecosystem partnerships with financial & insurance institutions, …”
4 · Who delivers
Matched suppliers (matched automatically)
| Safecote | United Kingdom | Not classified | active |
| Semios | Canada | Producer | active |
| String Bio | India | Research / RTO | active |
| Vland Biotech 蔚蓝生物 (SSE 603739) | China | Research / RTO | active |
| Vaxxinova Norway | Norway | Not classified | active |
| Agricultural Research Council (ARC) | South Africa | Research / RTO | active |
| Entobel | Vietnam | Producer | active |
| GenScript ProBio / Genscript | China | Research / RTO | active |
| Organica Biotech | India | Research / RTO | active |
| Sea6 Energy | India | Producer | active |
| UMITRON (SG subsidiary) | Singapore | Not classified | active |
| Cell AgriTech | Malaysia | Research / RTO | active |
In the services and supply catalogue 3 · paid service
Analytical & testing services · Laboratory & analytical instruments · Reagents & kits
Leading companies and institutes (from the brief)
| Company / Institute | Country | Key products / platforms | Tech features | Status 2026 |
|---|---|---|---|---|
| IDEXX Laboratories | 🇺🇸 United States | Reference-lab network, VetConnect Plus, Fecal Dx | PCR + antigen screening, LIMS-integrated, NASDAQ IDXX, 3.81 billion USD FY2024 | commercial |
| Zoetis | 🇺🇸 United States | Clarifide genomics, reference labs | Disease-resistance selection + pathogen monitoring, NYSE ZTS, 160 million USD Neogen deal | commercial |
| Eurofins | 🇱🇺 Luxembourg | Accredited food, feed & veterinary testing | ISO 17025 network, EU AMR and zoonosis panels | commercial |
| Friedrich-Loeffler-Institut | 🇩🇪 Germany | National reference lab, Radar Bulletin | BSL-3, avian-influenza molecular epidemiology, TSIS | operating |
| Harbin Veterinary Research Institute | 🇨🇳 China | AI & ASF reference platforms | BSL-3/ABSL-3, cross-species spillover modelling | research |
| ICAR-NIVEDI | 🇮🇳 India | National livestock disease informatics | Epidemiology, forecasting & forewarning of zoonoses | operating |
5 · Rules & route to market
Route into Russia / EAEU: FEED · Rosselkhoznadzor (expertise by VGNKI)
state registration within 45 working days after acceptance of documents (plus dossier and tests)
Information, not legal advice — confirm the procedure for your product. (2026-10-06)
state registration within 45 working days after acceptance of documents (plus dossier and tests)
Information, not legal advice — confirm the procedure for your product. (2026-10-06)
United States
The United States runs surveillance as a federated network of federal programmes and large commercial veterinary labs, with the private sector supplying most of the diagnostic throughput.
veterinary reference labs, NARMS AMR surveillance, fecal antigen screening#
- IDEXX Laboratories: a 3.81 billion USD (FY2024) veterinary diagnostics leader whose reference-lab network and VetConnect Plus software push PCR and antigen results into clinics; in May 2026 it expanded Fecal Dx to taeniid tapeworms including the zoonotic Echinococcus.
- Zoetis: the world’s largest animal-health company agreed in March 2026 to acquire Neogen’s animal-genomics unit for 160 million USD, integrating disease-resistance genomic selection (Clarifide) with pathogen monitoring across 120-plus countries.
- NARMS framework: the national antimicrobial-resistance monitoring system links human, retail-meat and animal isolates, the policy template that commercial One Health services report into.
European Union
The EU operates the most harmonised system, with legally fixed monitoring panels and a continent-wide veterinary surveillance network alongside accredited commercial testing.
harmonised AMR reporting, EARS-Vet network, metagenomic sentinel surveillance#
- EFSA & the EU Summary Report: EFSA compiles AMR in zoonotic and indicator bacteria from humans, animals and food under Directive 2003/99/EC and Decision (EU) 2020/1729, the binding reporting backbone.
- Friedrich-Loeffler-Institut (Germany): the federal animal-health institute is the national reference lab for avian influenza, issuing the monthly Radar Bulletin and feeding the TSIS notification system.
- Wageningen Bioveterinary Research & ALARUM: active One Health surveillance using long-read nanopore metagenomics to monitor and predict AMR, extended to low- and middle-income settings.
China
China centres surveillance on state veterinary research institutes and agricultural universities, coupling genomic pathogen labs with a national AMR-containment programme.
avian-influenza & ASF reference labs, livestock AMR governance, environmental microbiomes#
- Harbin Veterinary Research Institute (CAAS): the leading state R&D centre for avian influenza and African swine fever, operating BSL-3/ABSL-3 facilities to model cross-species transmission.
- China Agricultural University: runs AMR surveillance across livestock and environmental microbiomes and underpins cross-sectoral synergy governance for AMR control in China.
- National containment plan: the MoA-coordinated programme drives genomic surveillance of resistant organisms across the live-animal and food chain.
6 · Money: tenders & grants
7 · Tech stack & innovations
The service stack is built on untargeted sequencing, curated reference databases and accredited reporting pipelines that turn one sample into multi-hazard intelligence.
- Shotgun metagenomic sequencing (untargeted):
- Host-DNA depletion then tagmentation libraries sequenced on MGI DNBSEQ or Oxford Nanopore platforms, recovering pathogens and resistance genes in one run.
- Long-read nanopore data (the ALARUM and WBVR approach) resolves AMR genes together with their mobile genetic-element context, which short reads miss.
- Resistome and pathogen bioinformatics (CARD + Kraken2):
- Reads are taxonomically classified in Kraken2 and aligned against the CARD database of 5,000-plus resistance-gene references to quantify the resistome.
- Isolate genomes feed phylogenetic outbreak tracing and breakpoint comparison against the EU harmonised panels.
- AI spillover-risk scoring & LIMS reporting (ISO 17025):
- Pathogen and AMR profiles are scored for cross-species spillover risk (for example H5N1 at the poultry interface) and trended over time.
- Accredited LIMS dashboards emit EFSA- and NARMS-format reports, closing the loop to stewardship and trade decisions.
Sources 8 · 0 independent · 8 producer sites
Producers' own sites 8
- Idexx laboratories producer checked 2026-05-26 · link not kept
- Zoetis producer checked 2026-03-09 · link not kept
- Eurofins producer checked 2026-02-20 · link not kept
- Fli producer checked 2026-02-12 · link not kept
- Wageningen bioveterinary research producer checked 2026-02-27 · link not kept
- Hvri producer checked 2026-07-01 · link not kept
- Cau producer checked 2026-07-01 · link not kept
- Nivedi producer checked 2026-06-16 · link not kept