Technology · Health & biomedicine / Regenerative & personalized medicine

Organ manufacturing (3D-printed lungs, xenotransplantation)

Printing a lung scaffold from a digital model and seeding it with a patient's own stem cells, alongside xenotransplantation — still research, preclinical or early clinical, with first human trials targeted from 2025.

Maturity 3/9 Risk: high Advanced therapies US verified 2026-10-16 · 6 Sources

1 · What it gives

Organ manufacturing uses photopolymer-based printing to make complex, personalised scaffolds such as human lungs, then cellularises them with a patient’s own stem cells. Together with xenotransplantation it aims to replace conventional transplantation, which depends on a limited donor supply and often on immunosuppression. United Therapeutics, the primary company, reported its efforts at research, preclinical or early clinical stage as of 2024, with goals to start human trials for several programmes in 2025.

2 · What it replaces 6

D1	Enteric methane from cattle and sheep reduced by bromoform-containing red seaweed (Asparagopsis), essential-oil and plant-extract feed additives, and low-methane genetics — instead of unabated emissions and synthetic inhibitors alone Replaces: Unabated enteric methane; reliance on the synthetic inhibitor 3-nitrooxypropanol (3-NOP) as the only approved tool; ionophore antibiotics …	FEED
D1	Fermentation (stainless and single-use bioreactors, solid-state reactors) and downstream equipment (centrifuges, filtration, spray and fluid-bed drying, formulation) for local production of enzymes, microbial products and fermentation ingredients instead of chemical-synthesis plants and imports Replaces: Chemical-synthesis routes and imports for the products in FI-, FD-, I- and A-series articles (enzymes, organic acids, vitamins, microbial …	EAC
D1	Gas-fermented single-cell protein (methane, CO2 and industrial off-gas) instead of fishmeal and imported protein concentrates in feed Replaces: Fishmeal from reduction fisheries and imported soybean/rapeseed protein concentrates in compound feed (as a formula share)	FEED
D3	Genomic selection in dairy cattle breeding instead of progeny testing Replaces: Progeny testing — choosing AI bulls only after their daughters' milk records were available (5–6 years per bull and large testing costs)	BREED
D2	Industrial biocatalysis (enzymes and whole cells) — e.g. nitrile hydratase for acrylamide, engineered transaminase for sitagliptin, enzymatic antibiotic side-chain processes — instead of heavy-metal catalysts, high-pressure hydrogenation and multistep chemistry with toxic reagents Replaces: Copper-catalysed sulfuric-acid hydration of acrylonitrile; rhodium-catalysed high-pressure asymmetric hydrogenation; chemical deacylation of …	CHEM
D3	Insect-resistant (Bt) crop varieties — cotton, maize, soybean, eggplant — instead of broad-spectrum insecticide sprays against bollworms, stem borers and fruit borers Replaces: Repeated organophosphate, carbamate and pyrethroid sprays against lepidopteran pests (Helicoverpa, pink bollworm, Ostrinia/Sesamia corn …	GM

3 · How to implement 3 steps

1
Digital model
Create a 3D digital model of the organ.
2
Print the scaffold
Print the scaffold with bioprinting technology.
3
Cellularise
Seed the scaffold with patient-derived stem cells to develop functional tissue.

4 · Who delivers

Matched suppliers (matched automatically)

DICTA SAG Honduras	Honduras	Not classified	active
Food and Agricultural Research and Extension Institute (FAREI)	Mauritius	Research / RTO	active
World Agroforestry	Kenya	Research / RTO	active
YASCAI AND FAMILY PLC	Ethiopia	Producer	active
FENRI Co., Ltd.	Taiwan	Not classified	active
Henan Jiyuan Baiyun Industry Co., Ltd.	China	Producer	active
AGROSAVIA	Colombia	Research / RTO	active
ATTO	Brazil	Distributor	active
Absolute	India	Not classified	active
Afrique Phyto Plus - A2P SA	Côte d'Ivoire	Producer	active
Agri Phero Solutionz	India	Producer	active
AgriFam PT	Indonesia	Producer	active

Leading companies and institutes (from the brief)

United Therapeutics is named as the primary company, partnering with 3D Systems and CollPlant Biotechnologies. Others are matched by the portal under Advanced therapies.

5 · Rules & route to market

Route into Russia / EAEU: FEED · Rosselkhoznadzor (expertise by VGNKI)
state registration within 45 working days after acceptance of documents (plus dossier and tests)
Information, not legal advice — confirm the procedure for your product. (2026-10-06)

United States

The FDA oversees xenotransplantation and manufactured organs and requires preclinical studies and safety assessment before clinical trials can begin.

European Union

The sources reviewed on 2026-10-16 identified no the EU regulator or standard specific to this technology. Treat the route as case-by-case and ask for a check.

China

The sources reviewed on 2026-10-16 identified no China regulator or standard specific to this technology. Treat the route as case-by-case and ask for a check.

6 · Money: tenders & grants

Grant	First in Human and Early Stage Clinical Trials of Novel Investigational Drugs or Neuromodulatory Device-based … National Institutes of Health · United States	Oct 15, 2027 364 days
Grant	DEVCOM ARMY RESEARCH LABORATORY BROAD AGENCY ANNOUNCEMENT FOR FOUNDATIONAL RESEARCH Dept of the Army -- Materiel Command · United States	Nov 20, 2027 400 days
Grant	DOD Defense Health Agency (DHA) Research & Development FY23-FY27 BROAD AGENCY ANNOUNCEMENT for Extramural … Defense Health Agency Contracting Activity - DHACA · United States	Sep 30, 2027 349 days
Grant	Development of Collaborative Research Facilities or Research-Resource Facilities (C06 Clinical Trial Not … National Institutes of Health · United States	Jan 25, 2028 466 days
Grant	FY26 DEFENSE ESTABLISHED PROGRAM TO STIMULATE COMPETITIVE RESEARCH (DEPSCoR) – RESEARCH COLLABORATION (RC) Air Force Office of Scientific Research · United States	Apr 5, 2027 171 days

7 · Tech stack & innovations

Main risks from the sources: the complexity of lung architecture, the need for suitable bioinks, ensuring functional gas exchange, immune rejection, and high development and manufacturing cost.

Sources 6

Ir.unither.com — ir.unither.com 2026-10-16
Pubs.rsc.org — pubs.rsc.org 2026-10-16
3dsystems.com — www.3dsystems.com 2026-10-16
Ir.unither.com — ir.unither.com 2026-10-16
Ir.unither.com — ir.unither.com 2026-10-16
Pmc.ncbi.nlm.nih.gov — pmc.ncbi.nlm.nih.gov 2026-10-16