Technology · Agri-food systems / Agri-inputs & biocontrol

Precision multi-target biopesticides (RNAi)

Pesticides that use RNA interference to switch off specific pest genes instead of broad chemistry — moving from pilot to commercial, with the first sprayable dsRNA biopesticide approved by the US EPA in late 2023.

Maturity 6/9 Risk: medium Crop protection US · EU · CN verified 2026-10-16 · 3 Sources

1 · What it gives

Precision multi-target biopesticides use methods such as RNA interference to interfere precisely with pest gene expression or other critical biological processes. They replace conventional synthetic pesticides that persist in the environment and harm non-target species. The technology is moving from pilot to commercialisation: the first sprayable dsRNA biopesticide was approved by the US EPA in late 2023.

2 · What it replaces 6

D2	Crop disease forecasting models, spore traps, pheromone and smart pest traps and field diagnostics — spray when risk is real instead of calendar-based fungicide and insecticide programmes Replaces: Fixed-interval ("calendar") protective fungicide sprays and routine insecticide applications regardless of pest pressure	EAC
D2	Disease-resistant crop varieties (marker-assisted breeding, stacked resistance genes, cisgenesis) instead of routine fungicide spray programmes Replaces: Season-long protective fungicide programmes on susceptible varieties — e.g. 10–20 sprays of mancozeb/chlorothalonil/metalaxyl against potato …	SEED
D1	Enteric methane from cattle and sheep reduced by bromoform-containing red seaweed (Asparagopsis), essential-oil and plant-extract feed additives, and low-methane genetics — instead of unabated emissions and synthetic inhibitors alone Replaces: Unabated enteric methane; reliance on the synthetic inhibitor 3-nitrooxypropanol (3-NOP) as the only approved tool; ionophore antibiotics …	FEED
D1	Fermentation (stainless and single-use bioreactors, solid-state reactors) and downstream equipment (centrifuges, filtration, spray and fluid-bed drying, formulation) for local production of enzymes, microbial products and fermentation ingredients instead of chemical-synthesis plants and imports Replaces: Chemical-synthesis routes and imports for the products in FI-, FD-, I- and A-series articles (enzymes, organic acids, vitamins, microbial …	EAC
D1	On-farm and regional biofactories (multiplication units, media, quality control) for microbial bio-inputs — Bacillus, Trichoderma, Beauveria, Bt, beneficial insects — instead of importing finished chemical pesticides and fertilizers Replaces: Imported finished synthetic pesticides and part of mineral fertilizer programmes; also imported finished biologicals with long cold chains	EAC
D3	Agricultural spraying drones instead of knapsack and manned aerial spraying Replaces: Manual knapsack spraying, tractor spraying in small or wet fields, and manned aircraft/helicopter spraying	EAC

3 · How to implement 3 steps

1
Find gene targets
Identify and screen gene targets.
2
Produce
Produce at scale by recombinant fermentation or cell-free synthesis.
3
Formulate
Formulate, for example with nanotechnology, for stability and delivery.

4 · Who delivers

Matched suppliers (matched automatically)

Jaipur Bio Fertilizers	India	Services / consulting	active
Abtec	India	Research / RTO	active
Agilix International Limited	Singapore	Not classified	active
Avecom	Belgium	Research / RTO	active
Fishfa Bioscience Limited	India	Producer	active
Hebi Renyuan Biotech Devp. Co.,Ltd	China	Producer	active
Kanzagroup	Egypt	Producer	active
MoonBiotech 慕恩生物	China	Producer	active
Novobac	China	Producer	active
Restrain	United Kingdom	Producer	active
String Bio	India	Research / RTO	active
The Ecofarms and Agroservices Company	Nigeria	Producer	active

Leading companies and institutes (from the brief)

Silicon羿 Technology (Shanghai) is named as a provider with pilot production lines in China. Others are matched by the portal under Crop protection.

5 · Rules & route to market

Route into Russia / EAEU: EAC · EAEU accredited bodies / Rosakkreditatsiya
declaration registered within 3 working days (testing extra); certification longer
Information, not legal advice — confirm the procedure for your product. (2026-10-06)

United States

In the US the EPA approves these products under FIFRA.

European Union

In the EU approvals fall under Regulation (EC) 1107/2009.

China

Chinese authorities oversee approvals; the sources do not name a specific Chinese instrument.

6 · Money: tenders & grants

Grant	ARMY APPLICATIONS LAB BROAD AGENCY ANNOUNCEMENT FOR DISRUPTIVE APPLICATIONS Dept of the Army -- Materiel Command · United States	Apr 4, 2029 901 days
Grant	Automated Scientific Discovery – Food (RAISE pilot) European Commission · EU	Feb 2, 2027 109 days
Grant	Boosting Innovative GEOINT - Science & Technology Broad Agency Announcement (BIG-ST BAA) National Geospatial-Intelligence Agency · United States	Dec 14, 2026 59 days
Grant	CHIPS Research and Development Office (CRDO) Broad Agency Announcement (BAA) National Institute of Standards and Technology · United States	Sep 30, 2029 1080 days
Grant	DEVCOM ARMY RESEARCH LABORATORY BROAD AGENCY ANNOUNCEMENT FOR FOUNDATIONAL RESEARCH Dept of the Army -- Materiel Command · United States	Nov 20, 2027 400 days

7 · Tech stack & innovations

Main risks from the sources: off-target effects, regulatory hurdles, variable field efficacy and high production cost.

Sources 3

Nyncw.sh.gov.cn — nyncw.sh.gov.cn 2026-10-16
Frontiersin.org — www.frontiersin.org 2026-10-16
Doi.org — doi.org 2026-10-16